منابع مشابه
Tregitope: Immunomodulation powerhouse.
IVIG is frequently used in the 'pre-conditioning' regimens for higher risk transplants; its effects are attributed in part to induction of Tregs. We have identified regulatory T cell (Treg) epitopes, now known as Tregitopes, in IgG, the main component of intravenous immunoglobulin therapy (IVIg). Tregitopes provide one explanation for the expansion and activation of Treg cells following IVIg tr...
متن کاملTregitope update: mechanism of action parallels IVIg.
In the course of screening immunoglobulin G (IgG) sequences for T cell epitopes, we identified novel Treg epitope peptides, now called Tregitopes, contained in the highly conserved framework regions of Fab and Fc. Tregitopes may provide one explanation for the expansion and stimulation of Treg cells following intravenous immunoglobulin (IVIg) therapy. Their distinguishing characteristics includ...
متن کاملMaking proteins in the powerhouse.
Understanding regulation of mitochondrial DNA (mtDNA) expression is of considerable interest given that mitochondrial dysfunction is important in human pathology and aging. Similar to the situation in bacteria, there is no compartmentalization between transcription and translation in mitochondria; hence, both processes are likely to have a direct molecular crosstalk. Accumulating evidence sugge...
متن کاملUSTC: A powerhouse of talent.
A portion of the Chinese map showing several major cities surrounding Hefei, where USTC is located. Hefei is approximately one hour away from Nanjing and three hours away from Shanghai by train and the flight time from Hefei to Beijing is only two hours. As a UNESCO World Heritage Site, Yellow Mountain (or Huangshan) is known for its scenery, sunsets, peculiarly-shaped granite peaks, pine trees...
متن کاملEctopic Lymphoid Structures: Powerhouse of Autoimmunity
Ectopic lymphoid structures (ELS) often develop at sites of inflammation in target tissues of autoimmune diseases, such as rheumatoid arthritis, Sjögren's syndrome, multiple sclerosis, myasthenia gravis, and systemic lupus erythematosus. ELS are characterized by the formation of organized T/B cells aggregates, which can acquire follicular dendritic cells network supporting an ectopic germinal c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Human Immunology
سال: 2014
ISSN: 0198-8859
DOI: 10.1016/j.humimm.2014.10.012